Clomipramine Determination by Potentiometric PVC Membrane and Carbon Paste Sensors
نویسنده
چکیده
Clomipramine hydrochloride, active component of an antidepressant drug, was determined in the pharmaceutical formulation by two kinds of potentiometric sensor; a PVC membrane sensor and a carbon paste electrode modified by MWCNTs and ionic liquid. Both sensors were corporated with clomipramine-tetraphenylborate ion-pair complex and they respond based on ion exchange mechanism. The best PVC membrane sensor response was obtained by the membrane composition of 7% ion-pair, 30% PVC and 63% DBP, and in case of modified carbon paste electrode, the best response was obtained by a paste composed of 25% ion-pair, 5% MWCNTs, 25% ionic liquid and 45% graphite powder. The PVC membrane sensor showed a Nernstian response in the range of 1.0×10 -4 -1.0×10 -2 mol L -1 and modified carbon paste electrode 1.0×10 -5 -1.0×10 -2 mol L -1 . The both sensors work well in laboratory conditions in analysis of clomipramine hydrochloride in the tablet. KeywordsClomipramine hydrochloride, Potentiometry, Ion-selective Electrode, PVC Membrane, Sensor, MWCNTs, Carbon Paste Analytical & Bioanalytical Electrochemistry © 2012 by CEE www.abechem.com Anal. Bioanal. Electrochem., Vol. 4, No. 3, 2012, 315 – 326 316
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